Search results for " Apoptosis induction"

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SYNTHESIS AND PHOTOCHEMIOTHERAPEUTIC ACTIVITY OF THIOPYRANO[2,3-E]INDOL-2-ONES

2004

A series of derivatives of the new ring system thiopyrano[2,3-e]indol-2-one was prepared with the aim of obtaining new photochemotherapeutic drugs. Biological screenings were performed on this new class of photoactivable drugs and a strong antiproliferative effect was observed upon irradiation with UVA light. The compound bearing a methyl substituent at the pyrrole nitrogen resulted as the most interesting showing IC50 in the nanomolar range.

IndolesCell SurvivalUltraviolet RaysStereochemistryClinical BiochemistrySubstituentPharmaceutical ScienceHL-60 CellsRing (chemistry)BiochemistryChemical synthesischemistry.chemical_compoundCell Line TumorDrug DiscoveryThiolactoneHumansPhotosensitizerCytotoxicityMolecular BiologyIC50PyransPyrrolePhotosensitizing AgentsChemistryOrganic ChemistryDNA NeoplasmCombinatorial chemistrySettore CHIM/08 - Chimica FarmaceuticaThiopyrano-indoles Photochemotherapeutic activity Apoptosis inductionPhotochemotherapyMolecular MedicineCell Division
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